Stability properties of PrPSc from cattle with experimental transmissible spongiform encephalopathies: use of a rapid whole homogenate, protease-free assay
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منابع مشابه
Stability properties of PrPSc from cattle with experimental transmissible spongiform encephalopathies: use of a rapid whole homogenate, protease-free assay
BACKGROUND Transmissible Spongiform Encephalopathies (TSEs), including scrapie in sheep, chronic wasting disease (CWD) in cervids, transmissible mink encephalopathy (TME), and bovine spongiform encephalopathy (BSE), are fatal diseases of the nervous system associated with accumulation of misfolded prion protein (PrP(Sc)). Different strains of TSEs exist, associated with different PrP(Sc) confor...
متن کاملTransmissible Spongiform Encephalopathies
Neuronal death represents the primary pathology of neurodegenerative diseases such as Alzheimer's and Parkinson’s disease and Amyotrophic Lateral Sclerosis. These diseases usually present with a slow onset and a chronic progression. Various regions of the brain, spinal cord, or peripheral nerves may be affected, leading to functional impairment and neuron loss. Neurodegenerative diseases are of...
متن کاملHuman Transmissible Spongiform Encephalopathies
Creutzfeldt-Jakob disease (CJD) is a rare and fatal human neurodegenerative condition characterized in most cases by a rapidly progressive dementia, myoclonus, and a periodic electroencephalogram (EEG). It is classified as a transmissible spongiform encephalopathy (TSE) because it causes characteristic spongy degeneration of the brain and can be transmitted to laboratory animals. TSEs also affe...
متن کاملTransmissible spongiform encephalopathies
Keywords Disease name and synonyms Included diseases Definition Pathogenesis Sporadic CJD Genetic forms of TSE Acquired forms of TSE Treatment Conclusion References Abstract Human prion diseases or transmissible spongiform encephalopathies (TSE) are rare transmissible diseases affecting the central nervous system. The infectious agents are composed of an abnormal isoform of a host membrane prot...
متن کاملTransmissible spongiform encephalopathies.
Vet Med Today: Zoonosis Update 1705 T spongiform encephalopathies affect humans and other animals. Clinically, the diseases involve severe, progressive neurodegeneration with an invariably fatal outcome. The TSEs are linked by the unusual nature of their causative agent, which is believed to be a transmissible protein devoid of nucleic acid. This protein, known as a prion (a pseudoabbreviation ...
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ژورنال
عنوان ژورنال: BMC Veterinary Research
سال: 2013
ISSN: 1746-6148
DOI: 10.1186/1746-6148-9-167